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| 复方双黄连分散片的研制 | |
| 引用本文： | 刘郁,尹寿玉,刘连新.复方双黄连分散片的研制[J].时珍国医国药,2006,17(3):389-390. |
| 作者姓名： | 刘郁 尹寿玉 刘连新 |
| 作者单位： | 1. 延边大学医学院,吉林,延吉,133000;徐州工业职业技术学院,江苏,徐州,221000 2. 延边大学医学院,吉林,延吉,133000 3. 徐州工业职业技术学院,江苏,徐州,221000 |
| 摘 要： | 目的制备复方双黄连分散片。方法以崩解时间为指标,采用正交设计试验,对复方双黄连分散片处方进行筛选。结果微晶纤维素(MCC)为填充剂,羧甲基淀粉钠(CMS-Na)和交联聚乙烯吡咯烷酮(PVPP)为崩解剂,湿法制粒制备分散片。制定质量标准和溶出度实验。符合《中国药典》中有关分散片的要求。结论所制分散片处方合理,崩解快、溶出快而完全。 |
| 关 键 词： | 复方双黄连 分散片 正交设计 溶出度 高效液相色谱法 |
| 文章编号： | 1008-0805(2006)03-0389-02 |
| 修稿时间： | 2005年7月11日 |
Preparation of Fufang Shuanghuanglian Dispersible Tablets |
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| LIU Yu,YIN Shou-yu,LIU Lian-xin.Preparation of Fufang Shuanghuanglian Dispersible Tablets[J].Lishizhen Medicine and Materia Medica Research,2006,17(3):389-390. | |
| Authors: | LIU Yu YIN Shou-yu LIU Lian-xin |
| Abstract: | ObjectiveTo prepare the dispersible tablet of Fufang Shuanghuanglian.MethodsThe formulae of Fufang Shuanghuanglian dispersible tablet were optimized in terms of disintegrating time by orthogonal design test.ResultsThe tablet was prepared by compressing moist granulation,taking the microcrystalling cellulose(MCC) as the bulking agent,and the polyvinylpolyrrolidone(PVPP) and sodium carboxymethyl starch(CMS-Na) as the disintegrant.Also the estimation of its quality and dissolution were carried out.The quality of dispersible tablet of Fufang Shuanghuanglian reached to the standard of ChP(2000 edition).ConclusionThe dispersible tablet was stable.The dispersible tablet dissolved faster and more complete. |
| Keywords: | Fufang Shuanghuanglian Dispersible tablet Orthogonal design Dissolution HPLC |
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