Surfactant phosphatidylcholine composition during dexamethasone treatment in chronic lung disease |
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| Authors: | M R Ashton A D Postle D E Smith M A Hall |
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| Affiliation: | Department of Neonatal Medicine, Southampton University Hospitals NHS Trust;Department of Child Health, Faculty of Medicine, University of Southampton |
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| Abstract: | Objectives - To determine whether dexamethasone `matures' the phosphatidylcholine (PC) composition of broncheoalveolar fluid in infants at high risk of neonatal chronic lung disease (CLD), either by increasing the proportion of dipalmitoylphosphatidylcholine (DPPC), expressed as a percentage of total PC (%DPPC), or by increasing the ratio of DPPC to palmitoyloleoylphosphatidylcholine (DPPC:POPC ratio). |
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