碘缺乏和烟雾吸入对大鼠抗氧化能力的联合作用

[目的]探讨碘缺乏（ID）和烟雾吸入（SI）对大鼠抗氧化能力的联合作用。[方法]采用双因素析因实验设计,建立ID和SI实验模型,观察Wistar大鼠抗氧化能力的变化。[结果]实验6周后,ID因素使血清、甲状腺、卵巢等组织中脂质过氧化物（LPO）含量升高,甲状腺、大脑、肝、肾、脾等组织中超氧化物歧化酶（SOD）活性代偿性增强（P＜0．05或0．01）,并且降低大脑和肝中谷胱甘肽过氧化物酶（GSH－Px)活性;SI因素亦使大鼠抗氧化能力下降,其与ID因素的协同效应在甲状腺、大脑、卵巢等组织表现明显。[结论]在碘缺乏时,伴有烟雾吸入会进一步影响机体抗氧化能力,提示在碘缺乏病区吸烟或被动吸烟可能是该病发生发展的一个重要危险因素,控制吸烟也将有利于提高防治效果。

The Joint Action Effects of Iodine Deficiency and Smoke Inhalation on Antioxidation Ability of Rats

[Objective]The joint action of iodine deficiency (ID) and smoke inhalation (SI) on antioxidative ability of rats were studied in this paper[Methods]By employing 2 factor-factorial design principle,the ID and SI experimental model was established to investigate the joint action on the antioxidative ability of the Wistar rats[Results]After 6 weeks experimental period,the results showed that due to ID factor,the rats' lipid peroxide (LPO) contents increased significantly in serum,thyroid and ovary,the compensatory increase of superoxide dismutase (SOD) was noticed in thyroid,brain,liver,kidney and spleen(P<005 or 001),glutathione peroxidase(GSH-Px) activities decreased in liver and brainSI factor also influenced the antioxidative ability of ratsIts synergic effect associated with ID factor was significant in thyroid,brain and ovary[Conclusion]The results indicated that smoke inhalation should enhance the antioxidation injury when iodine supply was deficiencyIt was postulated that smoking or passive smoking maybe was an important risk factor of iodine deficiency disordersAnd smoking control might be helpful for its prevention and remediation