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| miRNA与内分泌代谢病 | |
| 引用本文： | 陈姬,曹仁贤. miRNA与内分泌代谢病[J]. 国际病理科学与临床杂志, 2007, 27(5): 14-433 |
| 作者姓名： | 陈姬 曹仁贤 |
| 作者单位： | 南华大学附属第一医院内分泌科,南华大学临床医学研究所,湖南,衡阳,421001;南华大学附属第一医院内分泌科,南华大学临床医学研究所,湖南,衡阳,421001 |
| 摘 要： | miRNA是近年来发现的一种内源性短序列非编码单链RNA,成熟的miRNA通过两种依赖于序列互补性的机制引起靶mRNA的降解或者抑制其翻译，在基因表达调控中扮演重要的角色。miRNA与内分泌代谢病关系密切，有潜在的生物治疗价值。 |
| 关 键 词： | miRNA 内分泌代谢病 胰岛素 |
| 收稿时间： | 2007-03-08 |
| 修稿时间： | 2007-04-17 |
miRNA and endocrine metabolic diseases |
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| CHEN Ji,CAO Ren-xian. miRNA and endocrine metabolic diseases[J]. Journal of International Pathology and Clinical Medicine, 2007, 27(5): 14-433 | |
| Authors: | CHEN Ji CAO Ren-xian |
| Affiliation: | Department of Endocrinology, First Affiliated Hospital of Nanhua University, Hengyang Hunan 421001,China |
| Abstract: | MicroRNAs(miRNAs) are recently discovered as endogenous non-coding single-strand RNAs of short sequence.MiRNAs cause degradation or translational repression of the mRNA targets through two mechanisms which depend on sequence complementary,so miRNAs play an important role in the regulation of gene expression.MiRNAs are closely related to the endocrine metabolic diseases,and they have potential biotherapy value. |
| Keywords: | microRNA endocrine metabolic diseases insulin |
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