急性脑梗死患者同型半胱氨酸和超敏C反应蛋白监测的临床意义

目的 探讨急性脑梗死患者同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)的变化及其临床意义.方法 经CT或MRI确诊的263例急性脑梗死患者为病例组,107例健康查体者作为对照组,采用免疫透射比浊法和ELISA法分别测定血清hs-CRP和血浆Hcy水平.结果 急性脑梗死患者血Hcy和hs-CRP水平均明显高于对照组(P<0.01);Hcy与hs-CRP水平依照LACI、POCI、PACI、TACI亚型排序逐渐增高(P<0.05,P<0.01),与疾病的严重程度呈现明显的正相关(r=0.43和r=0.52).结论 急性脑梗死患者Hcy和hs-CRP明显升高,并且与脑梗死的严重程度呈正相关,可作为预测急性脑梗死发生发展的敏感指标.

Clinical significance of homocystine and high-sensitivity C-reactive protein levels in patients with acute cerebral infarction

Objective To investigate the clinical significance of homocystine (Hey) and high-sensitivity C-reactive protein (hs-CRP) levels in the patients with acute cerebral infarction(ACI). Methods The levels of Hey and hs-CRP in 263 patients with ACI diagnosed by CT and MRI were measured using ELISA and immunoturhidimetry methods, respectively, which were compared to those in 107 healthy subjects. Results The levels of Hey and hs-CRP in the patients with ACI were significantly higher than those in healthy subjects (P<0. 01). The levels of Hey and hs-CRP were significantly increased in an order of LACI < POCI < PACI < TACI (P< 0. 05 or P< 0.01 ). In addition, the levels of Hey and Hs-CRP were positively correlated to the extent of cerebral infarction (r=0.43 and r=0.52). Conclusion The levels of Hey and hs-CRP are markedly increased in the patients with ACI, which are positively correlated to the severity of ACI and may be taken as the sensitive biochemical markers for predicting its development.