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| 黄连-大黄合煎蒽醌类成分溶出变化 | |
| 引用本文： | 霍志鹏,王玉,张兰兰,周水平,冯锋.黄连-大黄合煎蒽醌类成分溶出变化[J].中国实验方剂学杂志,2012,18(3):1-4. |
| 作者姓名： | 霍志鹏 王玉 张兰兰 周水平 冯锋 |
| 作者单位： | 1. 中国药科大学,南京 210009;天津天士力集团研究院中药所,天津 300410 2. 天津天士力集团研究院中药所,天津,300410 3. 中国药科大学,南京,210009 |
| 基金项目： | "重大新药创制"科技重大专项(2010ZX09401-406) |
| 摘 要： | 目的: 分析大黄-黄连不同配伍比例合煎时大黄中蒽醌类成分的溶出变化。方法: 水煎液经盐酸加热水解、三氯甲烷萃取等方法处理后,用RP-HPLC分析大黄单煎和配伍合煎液中5个蒽醌成分的溶出。结果: 黄连-大黄5个配伍比例(1∶2~2∶1之间)中芦荟大黄素、大黄素、大黄酚、大黄素甲醚等4个蒽醌类成分有不同程度溶出增加,大黄酸有较大幅度的溶出降低。结论: 在特定配伍比例范围内,配伍黄连对大黄中主要蒽醌成分有助溶作用。 |
| 关 键 词： | 黄连 大黄 配伍 蒽醌 溶出变化 |
| 收稿时间： | 2011/10/9 0:00:00 |
Dissolution Changes of Anthraquinones from Coptis chinensis and Rheum tangaticum Decoction |
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| HUO Zhi-peng,WANG Yu,ZHANG Lan-lan,ZHOU Shui-ping and FENG Feng.Dissolution Changes of Anthraquinones from Coptis chinensis and Rheum tangaticum Decoction[J].China Journal of Experimental Traditional Medical Formulae,2012,18(3):1-4. | |
| Authors: | HUO Zhi-peng WANG Yu ZHANG Lan-lan ZHOU Shui-ping and FENG Feng |
| Institution: | China Pharmaceutical University, Nanjing 210009, China;Traditional Chinese Medicine Research and Development Institute of Tasly Academy, Tianjin 300410, China;Traditional Chinese Medicine Research and Development Institute of Tasly Academy, Tianjin 300410, China;Traditional Chinese Medicine Research and Development Institute of Tasly Academy, Tianjin 300410, China;Traditional Chinese Medicine Research and Development Institute of Tasly Academy, Tianjin 300410, China;China Pharmaceutical University, Nanjing 210009, China |
| Abstract: | Objective: To analyze dissolution changes of anthraquinones from Rheum tangaticum in different compatibility ratio of R.tangaticum and Coptis chinensis.Method: After decoction and hydrochloric acid were hydrolyzed by heating,CHCl3 extraction method and so on,RP-HPLC method was used to analysis dissolution of five anthraquinones from single-boiled of R.tangaticum and compatibility decoction.Result: In five combination ratios of R.tangaticum-C.chinensis(1∶2-2∶1),dissolution of emodin,emodin,chrysophanol,and physcion had different degrees increased,dissolution of rhein decreased greatly.Conclusion: In range of specific compatibility ratio,compatibility with C.chinensis had solubilization effect for major anthraquinones from R.tangaticum. |
| Keywords: | Coptis chinensis Rheum tangaticum compatibility anthraquinone dissolution changes |
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