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Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa
Authors:Monica Bomba  Fabiola Corbetta  Alessandro Gambera  Franco Nicosia  Luisa Bonini  Francesca Neri  Lucio Tremolizzo  Renata Nacinovich
Affiliation:1. Clinic of Child and Adolescent Mental Health, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy;2. Department of Gynecological Endocrinology, Spedali Civili, Brescia, Italy;3. Geriatric Unit, Spedali Civili, Department of Medical and Surgery Sciences, University of Brescia, Brescia, Italy;4. Department of Childhood and Adolescent Neuropsychiatry, Spedali Civili, Brescia, Italy;5. Department of Neurology – University of Milano-Bicocca, San Gerardo Hospital, University of Milan Bicocca, Monza, Italy
Abstract:
Aim of this study consisted in assessing the 24-h heart rate variability (HRV), a measure of autonomic nervous system (ANS) imbalance, in 21 adolescents with functional hypothalamic amenorrhea (FHA, 11 normogonadotropic, N-FHA, and 10 hypogonadotropic, Hy-FHA) compared to 21 patients with anorexia nervosa (AN) and 21 controls. As expected, subjects with AN showed a significant dysregulation in multiple HRV parameters, while Hy-FHA patients presented with a dysregulation in a few domains (SDNN, HFr), which was not present in girls with N-FHA, who showed values largely similar to controls. FHA might represent part of the AN biological spectrum, and a link between these two conditions might exist, possibly related to the degree of psychological and/or hormonal dysfunction.
Keywords:Heart rate variability   Functional hypothalamic amenorrhea   Eating disorders   Anorexia nervosa   Adolescence   Autonomic nervous system
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