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| 内皮素－1对大鼠黄体细胞孕酮生成的影响 | |
| 引用本文： | 徐斯凡,赵白鸽,郑月慧,王忠兴,周寿康,赵伟,吴晓芸. 内皮素－1对大鼠黄体细胞孕酮生成的影响[J]. 生殖医学杂志, 1994, 0(3) |
| 作者姓名： | 徐斯凡 赵白鸽 郑月慧 王忠兴 周寿康 赵伟 吴晓芸 |
| 作者单位： | 江西医学院生理教研室，上海市计划生育科学研究所 |
| 基金项目： | 国家及江西省自然科学基金 |
| 摘 要： | 我们采用黄体细胞孵育的方法，观察了内皮素－１对离体黄体细胞孕酮生成的影响。发现内皮素－１能抑制黄体细胞孕酮的基础分泌及人绒毛膜促性腺激素（ＨＣＧ）刺激下的孕酮分泌。内皮素－１加入孵育的黄体细胞悬液１５分钟后，即发生明显地抑制孕酮分泌作用（Ｐ＜０．０１）。人内皮素－１的抗血清能反转内皮素－１的上述作用。实验结果提示，内皮素－１可能为一种卵巢内调节肽，它通过抑制黄体细胞的孕酮生成，参与黄体退化过程的调节 |
| 关 键 词： | 内皮素类，黄体孕酮激素类 |
Effect of endothelin-1 on progesterone production by rat luteal cells in vitro |
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| XU Sifan,ZHAO Baieg,ZHENG Yuehui,WANG Zhongxin,ZHOU Shoukang,ZHAO Wei,WU Xiaoyun. Effect of endothelin-1 on progesterone production by rat luteal cells in vitro[J]. Journal of Reproductive Medicine, 1994, 0(3) | |
| Authors: | XU Sifan ZHAO Baieg ZHENG Yuehui WANG Zhongxin ZHOU Shoukang ZHAO Wei WU Xiaoyun |
| Affiliation: | XU Sifan,ZHAO Baieg,ZHENG Yuehui,WANG Zhongxin,ZHOU Shoukang,ZHAO Wei,WU Xiaoyun Department of Physiology,Jiangxi Medical College,Nanchang 330006 Shanghai Institute of Planned Parenthood Research |
| Abstract: | The effect of endothelin- 1 on progesterone production by incubated rat luteal cells wasstudied in the present investigation, Endothelin-1 could inhibit the basic progesteroneproduction(10-7mol / L, p<0.05) and the progesterone secretion induced by hCG(10-9mol / L,P<0.05)from rat luteal cells. The beginning time is 15 min.The effect of endothelin-1 could be prevented speciallyby endothelin-1 antiserum.This study shows that endothelin-1 combines with its special binding sites onthe luteal cells, which leads to the decrease of progesterone production and suggests that endothelin-l isan intra-ovarian regulatory factor and is involved in the process ofcorpus luteum involution. |
| Keywords: | Endothelin Luteal Progesterone |
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