| 双侧乳腺癌基因和分子研究进展 |
| |
| 引用本文： | 余科达,邵志敏. 双侧乳腺癌基因和分子研究进展[J]. 国外医学(肿瘤学分册), 2006, 0(10) |
| |
| 作者姓名： | 余科达 邵志敏 |
| |
| 作者单位： | 复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系 |
| |
| 摘 要： | 双侧乳腺癌(BBC)是乳腺癌的一种特殊表现形式,其发病机制、生物学特性和预后都尚不明确。通过探索和研究乳腺癌相关基因如BRCA1、ATM、p53等,可以明确BBC的发病基础。BBC病灶的分子标记物及标记物间的相关性能较好显示BBC的生物学特性。可见基因和分子水平的研究是认识BBC的好方法。现综述近年来BBC基因和分子的研究进展。
|
| 关 键 词： | 乳腺肿瘤 双侧 基因 基因表达 疾病易感性 |
Progress in genetic and molecular study of bilateral breast cancer |
| |
| YU Ke- da. Progress in genetic and molecular study of bilateral breast cancer[J]. Foreign Medical Sciences (Cancer Section), 2006, 0(10) |
| |
| Authors: | YU Ke- da |
| |
| Affiliation: | YU Ke- da. Department of Breast Surgery,Cancer Hospital,Fudan University,Shanghai 200032,China |
| |
| Abstract: | Bilateral breast cancer (BBC) is a special type of breast cancer; its mechanism of pathogenesis, characteristics and prognosis are all unrevealed and controversial. Breast cancer related genes such as BRCA1 , ATM, p53 and so on are researched widely in order to identify the susceptible gene associated with BBC. What' s more, the molecular markers of the bilateral lesions and the relationship between them can indicate the biological features of BBC. It seems that research based on the gene and molecule may gradually reveal the pathogenesis and the essence of BBC. This paper will review the progress in genetic and molecular study of BBC in recent years. |
| |
| Keywords: | Breast neoplasms bilateral Genes Gene expression Disease susceptibility |
| 本文献已被 CNKI 等数据库收录！ |
