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Jejuketomycins A and B,polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151
Authors:Jun-Pil Jang  Gil Soo Kim  Tae Hoon Oh  Beomcheol Park  Minhee Kim  Gwi Ja Hwang  Hyeok-Won Lee  Jin-Gyeom Lee  Young-Soo Hong  Jong Seog Ahn  Sung-Kyun Ko  Jae-Hyuk Jang
Abstract:
Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.

Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151.
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