Altereporenes A–E,five epoxy octa-hydronaphthalene polyketides produced by an endophytic fungus Alternaria sp. YUD20002 |
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| Authors: | Dan-Dan Xia Hao-Jie Duan Fei Xie Tian-Peng Xie Yan Zhang Yue Sun Jian-Mei Lu Yu-Hong Gao Hao Zhou Zhong-Tao Ding |
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| Affiliation: | Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091 China.; College of Pharmacy, Dali University, Dali 671000 China ; The First People''s Hospital of Yunnan Province, Kunming 650034 China |
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| Abstract: | ![]()
Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes A–E (1–5) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum. Their structures were determined on the basis of comprehensive spectroscopic analyses, while the absolute configurations were elucidated by the comparison of experimental and calculated specific rotations. Meanwhile, the antimicrobial, cytotoxic, anti-inflammatory and acetylcholinesterase inhibitory activities of compounds 1–5 were also investigated.Five previously undescribed epoxy octa-hydronaphthalene polyketides, altereporenes A–E (1–5) were isolated from rice culture of the endophytic fungus Alternaria sp. YUD20002 derived from the tubers of Solanum tuberosum. |
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