妊娠期妇女感染HPV对产妇和胎儿的影响

目的分析妊娠期妇女感染人乳头瘤病毒(HPV)对产妇和胎儿的影响。方法选取116例感染人乳头瘤病毒的产妇作为实验组,另选取健康孕妇116例为对照组,分别对产妇分娩时羊水、胎盘组织及胎儿脐静脉血、口咽部分泌物与外阴分泌物中的HPV进行检测,分析产妇HPV的感染分型。随访1年,观察HPV感染对产妇和胎儿的影响。结果实验组中单型HPV感染及高危型HPV感染的患者所占比例较大,分别为66.38%和76.72%;患者宫颈肉眼形态异常炎症、细胞学检验呈鳞状上皮病变是感染HPV的危险因素;2组患者在分娩方式、产后出血及胎儿生长受限等方面比较,差异无统计学意义(P0.05);正常阴道分娩与剖宫产分娩的胎儿在羊水、胎盘组织及脐静脉血、口咽部分泌物、外阴分泌物或包皮分泌物中的HPV阳性检出率比较无显著差异(P0.05);胎儿HPV感染率为24.14%。结论单型HPV感染及高危型HPV感染是妊娠期妇女HPV感染的主要分型。

Influence of human papilloma virus infection on puerperas and fetus in pregnant women

Objective To analyze the influence of human papilloma virus (HPV) infection on puerperas and fetus in pregnant women.Methods A total of 116 pregnant women with infection of human papilloma virus were selected as experimental group,while 116 healthy pregnant women were selected as control group.Parturient in amniotic fluid,placenta and fetal umbilical venous blood,oropharyngeal secretion and vulva secretion of HPV were detected,and maternal HPV infection type was analyzed.After one year of follow up,the effect of HPV infection on maternal and fetal were observed.Results In the experimental group,single HPV infection and high-risk HPV infection were the main types,and the proportions were 66.38％ and 76.72％ respectively.The risk factors of HPV infection were cervical abnormality and cytology examination.There were no significant differences in the mode of delivery,postpartum hemorrhage and fetal growth restriction (P ＞ 0.05).There were no significant differences in the HPV positive rates in the amniotic fluid,placenta and umbilical venous blood,oropharynx,vulva secretion or wrapping secretion between fetus with normal vaginal delivery and cesarean delivery (P ＞ 0.05).The infection rate of fetal HPV was 24.14％.Conclusion Single type HPV infection and high risk type HPV infection are the main types in pregnant women with HPV infection.