Flunitrazepam for sleep disturbance in children with intractable epilepsy |
| |
| Affiliation: | 1. Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy;2. Child Neuropsychiatry Unit, Istituto G. Gaslini, Genoa, Italy;3. Department of Clinical Neurophysiology, Danish Epilepsy Centre and Aarhus University Hospital, Denmark;4. Department of Clinical and Experiential Epilepsy, UCL Institute of Neurology, University College London, London, UK;5. IRCCS Neuromed, Pozzilli, IS, Italy;6. Department of Clinical Neurosciences, Vaud University Hospital Center, Lausanne, Switzerland;7. Hospital Universitari Vall d''Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain;8. Sleep and Brain Plasticity Centre, Kings College London and Sleep Disorders Centre, GSTT NHS Trust, London, UK;1. Department of Neurology, The First Hospital of Jilin University, Changchun 130021, Jilin, China;2. Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Shanghai 201300, China;1. Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, 10400, Thailand;2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom;3. Kinshasa School of Public Health, University of Kinshasa, Avenue Tombalbaye 68-78, Democratic Republic of Congo;4. Mbale Clinical Research Institute (MCRI), P.O. Box 1966, Mbale, Uganda;5. Busitema University, P.O. Box 1460, Mbale, Uganda;6. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya;7. Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College London, SW7 2AS, United Kingdom;8. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand |
| |
| Abstract: | Add-on therapy with flunitrazepam (FNZ) was performed in 5 children with marked sleep disturbance and intractable seizures. Correction of the sleep disturbance was attained immediately after the start of FNZ administration in all patients. Furthermore, a significant decrease in the seizure frequency (3 patients) and improved quality of life (4 patients) were concomitantly observed. There was no adverse effect or interaction with conventional AEDs on long-term use. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
