Evaluation of bioadhesive buccal tablets containing triamcinolone acetonide in healthy volunteers |
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| Affiliation: | 1. Auckland Bone and Joint Research Group, Bone and Joint Research Group, 85 Park Road, Grafton, Auckland 1023, New Zealand;2. University of Auckland Medical School, 85 Park Road, Grafton, Auckland 1023, New Zealand;3. Department of Orthopedic Surgery, Auckland District Health Board, Auckland 1023, New Zealand;1. Harvard Radiation Oncology Program, Boston, Massachusetts;2. Departments of Radiology and Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands and Center for Health Decision Science, Harvard School of Public Health, Boston, Massachusetts;3. Department of Imaging, Dana-Farber Cancer Institute, Boston, Massachusetts;4. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas;5. Department of Radiation Oncology, Brigham and Women''s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts;1. Department of Pharmaceutics, National Organization for Drug Control and Research, Giza, 12654, Egypt;2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt;1. Department of Surgery – Otorhinolaryngology, Head & Neck Surgery, University of Adelaide, Adelaide, Australia;2. Department of Neurosurgery, Royal Adelaide Hospital, Adelaide, Australia;3. Adelaide Pathology Partners, Adelaide, South Australia, Australia;4. Wakefield Nasal and Sinus Institute, Wakefield Hospital, Wellington, New Zealand;5. Department of Chemistry, Otago University, Dunedin, New Zealand |
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| Abstract: | ![]()
The behaviour of bioadhesive buccal tablets prepared from different ratios of poly(acrylic acid-2,5-dimethyl-1,5-hexadiene) (PADH) and hydroxypropylmethylcellulose (HPMC) with and without triamcinolone acetonide (TAA) has been investigated in the buccal cavities of healthy human volunteers. The results indicate that tablets with a higher ratio of PADH swell faster, causing the disintegration of the tablets and consequently give rise to more rapid release of drug. The inclusion of higher percentages of HPMC provides more prolonged release of drug through its properties of gelling and slow dissolution. However, adhesion of the tablet is reduced in the excessive flow of saliva and there is also a tendency for the tablet to be dislodged from the mucosa. The tablet with a PADH/HPMC ratio of 50:50 seems to provide a suitable compromise for good bioadhesion and prolonged release of drug. |
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