Spectrophotometric determination of flunarizine dihydrochloride through the formation of charge-transfer complex with iodine |
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| Affiliation: | 1. Department of Chemistry, University of Science and Technology, Bannu-28100, KP, Pakistan;2. Department of Chemistry, Hazara University Mansehra-22310, KP, Pakistan;1. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Medicine, Chung Ang University, Dongjak-gu, Seoul 156-861, South Korea;3. LG Household & Health Care, Daejeon 305-343, South Korea;4. Department of BioNano Technology and Gachon BioNano Research Institute, Gachon University, Seongnam, Geonggi-do 461-701, South Korea;5. Department of Internal Medicine, Kangbuk Samsung Hospital and College of Medicine, Sungkyunkwan University, Seoul, South Korea;1. Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt;2. Chemistry Department, College of Science, Jouf University, P. O. Box 72341, Sakaka, Al-Jouf, Saudi Arabia;3. Egyptian Chemistry Administration, Ramses street, Cairo, Egypt |
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| Abstract: | ![]()
A spectrophotometric method is described for the assay of flunarizine dihydrochloride. The method is based on the molecular interaction between the drug and iodine, to form a charge-transfer complex in which the drug acts as n-donor and iodine as σ-acceptor. The iodine was found to form charge-transfer complex in a 1:1 stoichiometry with absorption bands at 295 and 355 nm. The concentrations were linear over 8–13 μg ml−1 at both 295 and 355 nm, respectively. A complete, detailed investigation of the formed complex was made with respect to its composition, associated constant and free energy change. The method has been applied successfully to the analysis of commercially available flunarizine dihydrochloride capsules without interference from the capsules excipient. To validate the proposed method, its accuracy and precision, the results were statistically compared with a newly developed reversed-phase HPLC procedure using Student-t and F-ratio tests. |
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