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Photodynamic Therapy with 5-aminolevulinic Acid 10% Gel and Red Light for the Treatment of Actinic Keratosis,Nonmelanoma Skin Cancers,and Acne: Current Evidence and Best Practices
Authors:Nathalie C. Zeitouni  Neal Bhatia  Roger I. Ceilley  Joel L. Cohen  James Q. Del Rosso  Angela Y. Moore  Gilly Munavalli  David M. Pariser  Todd Schlesinger  Daniel M. Siegel  Andrea Willey  Mitchel P. Goldman
Abstract:
Photodynamic therapy (PDT) can be an effective treatment for actinic keratosis (AK) as well as selected non-melanoma skin cancers (NMSCs), such as Bowen''s disease and superficial basal cell carcinoma. PDT has also demonstrated effectiveness in the management of acne vulgaris. Results from controlled clinical trials have shown the safety and efficacy of PDT for these conditions with the use of different photosensitizers and a wide range of light sources. PDT has been employed effectively as monotherapy and in combination with other topicals and alternate light or laser energy therapies. This article provides expert practical guidance for the use of the newest 5-aminolevulinic acid (ALA) product (ALA 10% gel) plus red light as monotherapy for AKs, NMSC, and acne. Here, information from clinical guidelines and a summary of supporting evidence is provided for each cutaneous condition. The authors also provide detailed guidance for employing ALA 10% gel, a photosensitizer precursor, for each of these applications.
Keywords:Photodynamic therapy   5-aminolevulinic acid gel   red light   actinic keratosis   acne   non-melanoma skin cancer   BF-200 ALA   Ameluz   BF-RhodoLED
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