2020年北京市朝阳区18岁及以上人群乙型肝炎血清流行病学调查题录

目的分析2020年北京市朝阳区≥18岁人群乙型肝炎(乙肝)的血清学感染状况。方法 2020年8-12月在北京市朝阳区按照多阶段整群随机抽样的方法, 对≥18岁常住居民采集静脉血并进行问卷调查, 样本量估算为8 525人。使用雅培微粒子发光法试剂盒检测HBsAg、抗-HBs、抗-HBc等乙肝血清学指标。结果调查对象为朝阳区≥18岁常住居民9 875人, HBsAg、抗-HBc、抗-HBs阳性率分别为2.8%(95%CI:2.5%～3.1%)、33.9%(95%CI:33.0%～34.9%)和45.6%(95%CI:44.6%～46.6%), HBsAg、抗-HBs和抗-HBc三项全阴率为45.9%(95%CI:44.9%～46.9%)。乙肝疫苗调查接种率为22.4%。18～28岁常住居民HBsAg和抗-HBc阳性率(1.9%和6.8%)显著低于其他年龄组;男性HBsAg和抗-HBc阳性率(3.6%和35.4%)均高于女性(2.2%和32.8%)。调查对象HBsAg、抗-HBs和抗-HBc三项全阴率随调查对象年龄增加而上升, 抗-HBs阳性率则逐渐下降。结论北京市朝阳区≥18岁人群HBsA...

A sero-epidemiological survey of hepatitis B virus among the population over 18 year old in Chaoyang District of Beijing, 2020

Objective To investigate the infection status of the hepatitis B virus among the population over 18 years old in the Chaoyang District of Beijing from August to December 2020.Methods A multistage stratified cluster random sampling was carried out on residents over 18 years old who lived in Chaoyang for more than six months in 2020. The estimated sample size was 8 525. A blood sample was collected and tested for HBsAg, anti-HBs, and anti-HBc using the Abbott Microparticle Enzyme Immunoassay method. A questionnaire survey was also conducted. Results A total of 9 875 residents were included; the overall positive rate of HBsAg, anti-HBc, and anti-HBs was 2.8% (95%CI:2.5%-3.1%), 33.9% (95%CI:33.0%-34.9%) and 45.6% (95%CI:44.6%-46.6%), respectively. The negative rate for all three serological markers was 45.9% (95%CI:44.9%-46.9%). The reported hepatitis B vaccination rate was 22.4%. The positive rate of HBsAg and anti-HBc were lower in group aged 18-28 years (1.9% and 6.8%, respectively) than the others, and that of the male was higher (3.6% and 35.4%, respectively) than the female (2.2% and 32.8%, respectively). The negative rate for all three serological markers increased with age. However, the positive rate of anti-HBs decreased with age. Conclusions In Chaoyang District of Bejing, HBV prevalence among the population over 18 years old has decreased. The publicity and education about hepatitis B prevention and control should be strengthened to reduce the immunization gap of the population further.