| 怀牛膝根成分的分离与鉴定 |
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| 引用本文： | 贾淑萍,俞智勇,郝志芳,李建新. 怀牛膝根成分的分离与鉴定[J]. 中国中药杂志, 2006, 31(15): 1244-1247 |
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| 作者姓名： | 贾淑萍 俞智勇 郝志芳 李建新 |
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| 作者单位： | 1. 南京大学,化学化工学院,江苏,南京,210093;渤海大学,化学化工学院,辽宁,锦州,121000
2. 南京大学,化学化工学院,江苏,南京,210093 |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | 目的：研究怀牛膝Achyranthes bidentata根的三萜类化学成分。方法：利用凝胶、正相和反相硅胶色谱反复进行分离和纯化，通过理化、质谱和核磁共振波谱等技术鉴定化合物结构。结果：从怀牛膝根的水溶部分中分离得到7个化合物，分别鉴定为牛膝皂苷A(achyranthoside A，1)、牛膝皂苷E(achyranthoside E，2)、木鳖子皂苷Ib(momordin Ib，3)、竹节参苷IVa(chikusetsusaponin IVa，4)、竹节参苷IVa甲酯(chikusetsusaponin IVa methyl ester，5)、竹节参苷V(chikusetsusaponin V，6)、竹节参苷V甲酯(chikusetsusaponin V methyl ester，7)。结论：化合物1和2为首次从该植物根中分离得到的天然化合物。
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| 关 键 词： | 怀牛膝 三萜 皂苷 牛膝皂苷A 牛膝皂苷E 色谱法 |
| 文章编号： | 1001-5302（2006）15-1244-04 |
| 收稿时间： | 2005-09-24 |
| 修稿时间： | 2005-09-24 |
Isolation and identification of triterpenoids from root of Achyranthes bidentata in Henan |
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| JIA Shu-ping ;YU Zhi-yong;HAO Zhi-fang;LI Jian-xin. Isolation and identification of triterpenoids from root of Achyranthes bidentata in Henan[J]. China Journal of Chinese Materia Medica, 2006, 31(15): 1244-1247 |
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| Authors: | JIA Shu-ping YU Zhi-yong HAO Zhi-fang LI Jian-xin |
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| Affiliation: | 1.School of Chemistry and Chemical Engineering,Nanjing University ,Nanjing 210093 ,China;2. School of Chemistry and Chemical Engineering ,Bohai University ,Jinzhou 121000,China |
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| Abstract: | Objective: To investigate the triterpenoids from root of Achyranthes bidentata in Henan. Method: Sephadex,normal-and reversed-phase column chromatographies were applied for the isolation and purification. The structure determinations were performed by means of physiochemical properties,MS and NMR data analyses. Result: Seven compounds were isolated from the water soluble fraction in root of A. bidentata,and determined as achyranthoside A (1),achyranthoside E (2),momordin Ib (3),chikusetsusaponin IVa (4),chikusetsusaponin IVa methyl ester (5),chikusetsusaponin V (6),chikusetsusaponin V methyl ester (7). Conclusion: Compounds 1 and 2 were isolated from the natural resources for the first time. |
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| Keywords: | Achyranthes bidentata triterpenoids saponins achyranthoside A achyranthoside E chromatography |
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