| 荞麦花叶总黄酮抗四氯化碳肝损害的实验研究 |
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| 引用本文： | 储金秀,王树华,韩淑英,刘淑梅,朱丽莎,辛念.荞麦花叶总黄酮抗四氯化碳肝损害的实验研究[J].华北煤炭医学院学报,2005,7(5):553-554. |
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| 作者姓名： | 储金秀 王树华 韩淑英 刘淑梅 朱丽莎 辛念 |
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| 作者单位： | 华北煤炭医学院基础部药理学教研室,河北唐山,063000 |
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| 摘 要： | ①目的探讨养麦花叶总黄酮（TFBFL）对四氯化碳（CCl4）所致肝损害的保护作用。⑦方法50只昆明种小鼠随机分为5组。测定各组小鼠的8ALT、IALT；肝组织SOD、GSH、TG、TC；计算肝脏指数（LI）；观察肝脏病理变化；井对各组指标进行比较。③结果与四氯化碳模型组比较，经TFBFL预防性治疗后，小鼠sALT、IALT和肝组织MDA、TG、TC的含量覆L1均明显降低，而肝脏SOD和GSH活力显著增强（P〈0．05）。通过病理学切片观察。TFBFL能明显改善肝组织的病理变化。④结论TFBFL对四氯化碳造成的小鼠急性肝损伤具有很好的保护作用。
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| 关 键 词： | 肝损害 荞麦 总黄酮 四氯化碳 |
| 文章编号： | 1008-6633(2005)05-0553-02 |
| 收稿时间： | 03 21 2005 12:00AM |
| 修稿时间： | 2005年3月21日 |
Experimental study on total flavonoids of buckwheat flowers and leaves on mice hepatic injury induced by CCl4 |
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| CHU Jinxiu, WANG Shuhua, HAN Shuying, et al.Experimental study on total flavonoids of buckwheat flowers and leaves on mice hepatic injury induced by CCl4[J].Journal of North China Coal Medical College,2005,7(5):553-554. |
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| Authors: | CHU Jinxiu WANG Shuhua HAN Shuying |
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| Institution: | Pharmacologic department, North China Coal Medical College, Tangshan 063000 |
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| Abstract: | Objective The protective effect of total flavonoids of buckwheat flowers and leaves on CCl4-induced hepatic injury in mice was observed.Methods Fifty Kunming mice were divided into 5 groups randomly.The level of sALT,lALT,and MDA,SOD,GSH,TG,TC in liver,and LI of the mice were determined.Hepato-pathologic changes of mice were observed with light microscopy.Results Compared with model control group,the levels of sALT,lALT,liver MDA,TG,TC and LI of the mice treated with TFBFL were significantly decreased,while the activities of SOD and GSH increased greatly(P<0.05).By observation of pathological slices,TFBFL could improve hepatic pathological changes distinctly.Conclusion TFBFL could prevent CCl4-induced haptic injury. |
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| Keywords: | Buckwheat Total flavonoids Carbon tetrachloride Hepatic injury |
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