| 大黄诱导急性胰腺炎大鼠早期腺泡细胞凋亡的研究 |
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| 引用本文： | 顾群浩,张晓东,张成刚,沙盈盈,张胜华.大黄诱导急性胰腺炎大鼠早期腺泡细胞凋亡的研究[J].辽宁中医杂志,2007,34(3):366-367. |
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| 作者姓名： | 顾群浩 张晓东 张成刚 沙盈盈 张胜华 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院普外科,上海,200437 |
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| 基金项目： | 上海中医药大学资助项目（03X-55） |
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| 摘 要： | 目的:探讨大黄素治疗急性胰腺炎(AP)的作用机理。方法:SD大鼠32只,随机分为对照组、急性胰腺炎模型组、大黄素治疗组,用雨蛙素制作大鼠AP模型,大黄素组分成二个亚组,分别在模型制作后1h、12h腹腔内注射大黄素2.5mg/kg,2h后重复1次,测定24h后各组大鼠血清TNF-α、IL-6,并取胰腺组织作病理学检查,同时应用TUNEL技术分析大鼠胰腺腺泡细胞凋亡的变化。结果:发现造模1h后大黄素给药组血清TNF-α、IL-6水平明显降低,胰腺组织病变程度减轻,胰腺腺泡细胞凋亡指数较模型组高(P<0.05)。造模12h后大黄素给药组与模型组无显著差异。结论:早期给予大黄素可明显抑制大鼠TNF-α、IL-6的释放,诱导胰腺腺泡细胞凋亡,从而改善大鼠AP的病情发展。
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| 关 键 词： | 急性胰腺炎 早期 大黄素 凋亡 |
| 文章编号： | 1000-1719(2007)03-0366-02 |
| 修稿时间： | 07 21 2006 12:00AM |
Study of Emodin on Pancreatic Acinar Cell Apoptosis at Early Stage of Acute Pancreatitis in Rats |
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| GU Qun-hao,ZHANG Xiao-dong,ZHANG Cheng-gang,SHA Ying-ying,ZHANG Sheng-hua.Study of Emodin on Pancreatic Acinar Cell Apoptosis at Early Stage of Acute Pancreatitis in Rats[J].Liaoning Journal of Traditional Chinese Medicine,2007,34(3):366-367. |
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| Authors: | GU Qun-hao ZHANG Xiao-dong ZHANG Cheng-gang SHA Ying-ying ZHANG Sheng-hua |
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| Institution: | Dept. of General Surgery, Yueyang Hospital Attached to Shanghai University of TCM, Shanghai 200437, China |
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| Abstract: | Objective:To study the mechanism of emodin on acute pancreatitis.Methods:32 SD rats were randomly divided into control group,acute pancreatitis group and emodin group.Caerulein was injected to establish acute pancreatitis models.After that,emodin was injected intraperitonealy 1h or 12h later.Then we examine the changes of serum amylase,TNF-α,IL-6 and apoptosis index.Results:When emodin was injected early,the level of serum amylase,TNF-α,IL-6 was lower and apotosis index was higher than that in the acute pancreatitis group(P<0.05).Conclusion:Emodin,injected early,can induce pancreatic acinar cell apoptosis,and decrease the level of infection factors. |
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| Keywords: | acute pancreatitis early stage emcdin apoptosis |
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