Identification of two new HLA-DRB1 alleles: HLA-DRB1*1350 and DRB1*140502 |
| |
Authors: | Chen Z X Tsan S G Dang C W Chu C C Lin M Lee Y J |
| |
Affiliation: | Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan. |
| |
Abstract: | Two new HLA-DRB1 alleles have been found by using high-resolution sequence-based typing. The two sequences have been officially named DRB1*1350 (HWS10001327-AY048687) and DRB1*140502 (HWS10001790-AY129430). DRB1*1350 differs from DRB1*110101 by two amino acids at positions 37 (Y-->N) and 58 (A-->E). This allele may arise from gene conversion between DRB1*110101 and DRB1*130201 or DRB1*030101, which are commonly found in Taiwan populations. The other allele, DRB1*140502, obtained from a patient with rheumatoid arthritis, differs from DRB1*140501 at codon 58 (GCC-->GCT). However, it causes no change in amino acid sequence and would therefore not have direct clinical implications. |
| |
Keywords: | HLA-DRB1*1350 HLA-DRB1*140502 |
本文献已被 PubMed 等数据库收录! |
|