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Dendritic cell based vaccination strategy: an evolving paradigm
Authors:Anna C. Filley  Mahua Dey
Affiliation:1.Department of Medico-Surgical Sciences and Biotechnologies,“Sapienza” University of Rome,Latina,Italy;2.Department of Translational Medical Science,University of Naples “Federico II”,Naples,Italy;3.Department of Advanced Biomorphological Sciences,University of Naples “Federico II”,Naples,Italy;4.Department of Public Health,University of Naples “Federico II”,Naples,Italy;5.Department of Neurosciences, Reproductive Sciences and Odontostomatology,University of Naples “Federico II”,Naples,Italy
Abstract:
The basement membrane collagen IV-degrading matrix metalloproteinases -2 and -9 (MMPs) are most often linked to the malignant phenotype of tumor cells by playing a critical role in invasion, metastasis, angiogenesis, and vasculogenesis. We verified the activity of these two MMPs in the sera of patients affected by brain tumors (20 gliomas, 28 meningiomas and 20 metastasis) by zymography. The sera of 25 healthy volunteers with no concomitant illnesses were used for controls. Zymography showed four dominant gelatinolytic bands of 240, 130, 92 (MMP-9) and 72 (MMP-2) kDa. No statistically significant variations of MMP-2 proteolytic activity between patients and healthy individuals were observed. On the contrary, MMP-9 (both monomeric and multimeric forms) lytic activities were significantly higher in tumors specimens compared to healthy controls (p?
Keywords:
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