胎儿生长发育与脐血促肾上腺皮质激素及皮质醇的关系

目的:研究促肾上腺皮质激素(ACTH)?皮质醇(Cor)与胎儿生长发育的相关性?方法:根据出生体重与胎龄的关系将新生儿分为3组:小于胎龄儿(SGA组)30例?大于胎龄儿(LGA组)30例?适于胎龄儿(AGA组)30例,分别测定出生时身长?体重,放射免疫法测定脐血ACTH以及Cor水平?结果:脐血ACTH水平分别为:LGA组(26.46 ± 7.73) ng/ml?AGA组(28.64 ± 7.12)ng/ml?SGA组(29.30 ± 8.33) ng/ml,三组间比较无显著差异(P = 0.336),脐血Cor水平分别为LGA组(7.11 ± 2.70) ng/ml?AGA组(11.84 ± 3.88) ng/ml?SGA组(18.80 ± 5.27) ng/ml,三组间比较:SGA组>AGA组>LGA组,各组间比较差异均有统计学意义(P < 0.01)?结论:血清Cor与胎儿生长发育相关,对生长发育起调节作用?

Studies on the relations between fetal growth and cord blood ACTH and crotisol

Objective:To investigate the relationship between fetal growth and cord blood adrenocorticotropic hormone (ACTH) and crotisol. Methods: The newborns were divided into three groups according to their born weight and gestational age,small for gestational age(SGA group,n = 30),lager for gestational age(LGA group,n = 30),appropriate gestational age(AGA group,n = 30). Born body length and body weight of three groups were measured respectively. The levels of ACTH and crotisol in cord blood were measured by radioimmunoassay(RIA). Results: The levels of ACTH in cord blood were (26.46 ± 7.73) ng/ml,(28.64 ± 7.12) ng/ml and (29.30 ± 8.33) ng/ml in LGA group,AGA group and SGA group respectively,and there were no significant differences among three groups(P = 0.336). The levels of crotisol in cord blood were (7.11 ± 2.70) ng/ml,(11.84 ± 3.88) ng/ml and (18.80 ± 5.27) ng/ml in LGA group,AGA group and SGA group respectively,and there were significant differences among three groups(P < 0.01). Conclusion: Crotisol might play an important role in fetal growth.