首页 | 本学科首页   官方微博 | 高级检索  
     


A Systematic Review of the Predictive Value of 18FDG-PET in Esophageal and Esophagogastric Junction Cancer After Neoadjuvant Chemoradiation on the Survival Outcome Stratification
Authors:Pascaline Schollaert  Ralph Crott  Claude Bertrand  Lionel D’Hondt  Thierry Vander Borght  Bruno Krug
Affiliation:1. Nuclear Medicine Division, CHU UCL Mont-Godinne – Dinant, Université Catholique de Louvain, 1 Dr Therasse, 5530, Yvoir, Belgium
2. Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium
3. Surgery, CHU UCL Mont-Godinne – Dinant, Université Catholique de Louvain, Yvoir, Belgium
4. Oncology, CHU UCL Mont-Godinne – Dinant, Université Catholique de Louvain, Yvoir, Belgium
Abstract:

Purpose

We studied the predictive value of [18?F]fluorodeoxyglucose-positron emission tomography (18FDG-PET) for assessing disease-free (DFS) and overall survival (OS) in esophageal and esophagogastric junction cancer.

Materials and methods

A literature search (PUBMED/MEDLINE, EMBASE, Cochrane) was performed to identify full papers with 18FDG-PET and survival data, using indexing terms and free text words. Studies with >10 patients with locally advanced esophageal cancer, presenting sequential or at least one post-adjuvant treatment 18FDG-PET data and Kaplan–Meier survival curves with >6 months median follow-up period were included. We performed a meta-analysis for DFS and OS using the hazard ratio (HRs) as outcome measure. Sources of heterogeneity study were also explored.

Results

We identified 26 eligible studies including a total of 1,544 patients (average age 62 years, 82 % males). The TNM distribution was as follows: stage I 7 %, II 24 %, III 53 % and IV 15 %. The pooled HRs for complete metabolic response versus no response were 0.51 for OS (95 % CI, 0.4–0.64; P?Conclusion Despite methodological and clinical heterogeneity, metabolic response on 18FDG-PET is a significant predictor of long-term survival data.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号