Anti-fecundity immunity in mice immunized with anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum

Objective To observe the effects of anti-fecundity and anti-embryonation immuntiy of anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum on female adult worm. Methods The active immunization of C57BL/6 mice was conducted by means of three intraperitoneal injections of NP30.The control group was injected with SP2/0 ascites intraperitoneally. Results On the twenty-seventh day after challenge infection, the number of eggs in the liver tissue and in uterus of the group immunized with NP30 decreased by 30.91% and by 38.55%, respectively.On the thirty-ninth day after the challenge infection, the number of mature eggs in the liver tissue of the group immunized with NP30 decreased by 66.63% and the number of dead eggs increased by 60.66%. Conclusions NP30, with which mice were actively immunized, possesses double effects of anti-fecundity and anti-embryonation immunity on female adult worm of Schistosoma japonicum, therefore it can be used as a promising candidate of anti-pathologic vaccine molecule against Schistosomiasis japonica.