Tolerability and safety of topiramate in Chinese patients with epilepsy : an open-label, long-term, prospective study |
| |
Authors: | Lu Yang Wang Xuefeng Li Qihua Li Jingmei Yan Yong |
| |
Institution: | The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. |
| |
Abstract: | OBJECTIVES: This study focused on (i) evaluating the long-term tolerability and safety of topiramate in Chinese patients with epilepsy, and (ii) comparing the tolerability and safety of topiramate monotherapy versus polytherapy in the same population. METHODS: This was a prospective, open-label, long-term (36 months) clinical trial. 320 patients (275 adults and 45 children) with epilepsy were recruited into the study; of these, 156 patients had generalised seizures, 151 patients had partial seizures and 13 patients had unclassifiable seizures. All patients received topiramate approximately 200 mg/day either as monotherapy or as adjunctive therapy. At each visit, a physical examination and routine laboratory analysis were performed, and the adverse event (AE) profile was obtained by face-to-face interview. RESULTS: 268 patients received topiramate
|
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|