Anti-Hepatitis A Virus Immunoglobulin M Antibodies in Urine Samples for Rapid Diagnosis of Outbreaks |
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| Authors: | Licel de los Angeles Rodrí guez Lay, Osmany Larralde Dí az, Raiza Martí nez Casanueva, Aidonis Guti rrez Moreno |
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| Affiliation: | Licel de los Angeles Rodríguez Lay, Osmany Larralde Díaz, Raiza Martínez Casanueva, and Aidonis Gutiérrez Moreno |
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| Abstract: | ![]()
The main goal of this study was to test the feasibility of using urine for diagnosing hepatitis A virus (HAV) infections. A correlation of 90.78% between the test results of urine and serum samples was obtained. Four outbreaks of hepatitis A were confirmed by testing only urine samples. The levels of anti-HAV immunoglobulin M (IgM) antibodies in urine samples remained stable during 6 months of storage at −70°C but decreased when the samples were stored at 4°C. The results of tests of samples obtained 2 and 6 months after infection suggested that IgM levels decline more rapidly in urine than in serum. |
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