| 乙型肝炎病毒前S1蛋白在血清学诊断乙肝病毒复制中的研究 |
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| 引用本文： | 李果,高兵,孙自镛.乙型肝炎病毒前S1蛋白在血清学诊断乙肝病毒复制中的研究[J].临床血液学杂志,2008,21(6):627-629. |
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| 作者姓名： | 李果 高兵 孙自镛 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院检验科,武汉430030 |
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| 摘 要： | 目的：探讨前S1蛋白（Pre—S1）在血清学诊断乙肝病毒复制中的意义。方法：选择慢性乙型肝炎患者血清250例。分别测定每份患者血清中HBV标志物、前S1蛋白和HBV DNA。结果：HBeAg（＋）组中前S1蛋白阳性率97．2％（70／72），HBV DNA阳性率100％（72／72）。HBeAg（-）组中前S1蛋白阳性率60．1％（107／178），HBV DNA阳性率63．5％（113／178）。前S1蛋白和HBV DNA的总符合率为89．6%（224／250），2者差异无统计学意义（P〉0．05）。HBeAg和HBV DNA的总符合率为54．8％（137／250），2者差异有统计学意义（P〈0．01）。HBsAg（-）中检出前S1蛋白阳性2例。结论：前S1蛋白比HBeAg更敏感地反映HBV复制情况，且可弥补由于HBsAg基因编码区突变造成的漏诊。
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| 关 键 词： | 前S1蛋白 乙肝病毒DNA 乙肝标志物 |
Study of hepatitis B virus pre-S1 in diagnosing viral replication in chronic hepatitis patients |
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| LI Guo GAO Bing SUN Ziyong.Study of hepatitis B virus pre-S1 in diagnosing viral replication in chronic hepatitis patients[J].Journal of Clinical Hematology,2008,21(6):627-629. |
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| Authors: | LI Guo GAO Bing SUN Ziyong |
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| Institution: | LI Guo GAO Bing SUN Ziyong (Department of medical laboratory,Tongji Hospital,Tongji Medical College,Huazhong University of Science , Technology,Wuhan,430030,China) |
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| Abstract: | Objective:To study the clinical significance of HBV Pre-S1 in diagnosing viral replication in chronic hepatitis patients. Method:250 chronic hepatitis patients were selected randomly.Serum Pre-S1 and HBV markers were determined by enzyme immunoassay(EIA) and HBV DNA was tested by polymerase chain reaction(PCR). Result:The positive rates of Pre-S1 and HBV DNA in the patients with HBeAg(+) were 97.2% and 100%,respectively.The positive rates of Pre-S1 and HBV DNA in the patients with HBeAg(-) were 60.1% and 63... |
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| Keywords: | Pre-S1 protein HBV DNA HBV-Markers |
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