| 转化生长因子-β1对瘢痕疙瘩成纤维细胞 SMAD3,7表达的影响 |
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| 引用本文： | 杨力,李荟元,郭树忠,韩岩,汤苏阳,张琳西,舒茂国,潘宝华. 转化生长因子-β1对瘢痕疙瘩成纤维细胞 SMAD3,7表达的影响[J]. 中国组织工程研究与临床康复, 2003, 7(6): 1006-1007 |
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| 作者姓名： | 杨力 李荟元 郭树忠 韩岩 汤苏阳 张琳西 舒茂国 潘宝华 |
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| 作者单位： | Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China |
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| 摘 要： | ![]()
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The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid- derived fibroblasts |
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| Yang Li. The effect of transforming growth factor-β1 on expression of SMAD3 and SMAD7 in keloid- derived fibroblasts[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(6): 1006-1007 |
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| Authors: | Yang Li |
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| Abstract: | ![]()
AIM: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β 1 ( TGF-β 1) on keloid- derived fibroblasts. METHODS: The expression of SMAD3 (at 1,2,4,24,48 h)and SMAD7(at 0.5 1,1.5, 2,4,24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β 1 were added to the monolayer culture system.RESULTS: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used.CONCLUSION: TGF-β 1 may down regulate the expression of SMAD3,but up regulate that of SMAD7 . |
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| Keywords: | transforming growth factor bata keloid fibroblasts |
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