姜黄素抗肝纤维化的实验研究

目的：探讨姜黄素对四氯化碳（CCl4)中毒性纤维化的治疗作用。方法：复制大鼠CCl4肝纤维化模型，以马洛替酯为阳性对照，采用光镜观察组织学改变，测定血清谷丙氨酸转移酶（ALT），谷草氨酸转移酶（AST），一氧化氮（NO），透明质酸（HA），层粘连蛋白（LN），肝组织羟脯氨酸（Hyp，丙二醛（MDA）以反映肝细胞损伤及肝纤维化的程度。结果：姜黄素能降低实验性肝纤维化大鼠血清中升高的ALT,AST,NO,HA,LN水平和过高的肝组织中Hyp,MDA的含量。病理组织学检查亦表明，姜黄素明显改善实验性肝纤维化。结论：姜黄素可能对实验性肝纤维化具有一定的治疗作用。

Effect of Curcumin against CCl4-Induced Liver Fibrosis in Rats

Objective:To investigate the curative effect of curcumin on liver fibrosis in rats induced by CCl 4.Methods:Model of liver fibrosis in rats was induced by CCl 4 by subcutaneous injection of CCl 4 and they were treated with curcumin or malotilate as positive control. The histological changes were observed with microscope. The levels of ALT,AST,NO,HA,LN in serum and Hyp, MDA in liver tissue were determined to reveal the event liver damage.Results:Curcumin significantly reduced the elevate levels of ALT, AST, NO, HA, LN in serum and Hyp, MDA in liver tissue. Pathological examination suggested curcumin has therapeutic effect on experimental liver fibrosis wih significant.Conclusion:Curcumin may have therapeutic effect on CCl 4-induced liver fibrosis in rats.