| 高效液相色谱法测定血浆中阿魏酸钠含量 |
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| 引用本文： | 任志强,刘丽君,龙艾兵,李宪为.高效液相色谱法测定血浆中阿魏酸钠含量[J].中国药房,2003,14(1):33-34. |
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| 作者姓名： | 任志强 刘丽君 龙艾兵 李宪为 |
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| 作者单位： | 湖南省益阳市中心医院,益阳市413000 |
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| 摘 要： | 目的 :建立一种测定血浆中阿魏酸钠浓度的高效液相色谱法。方法 :以C18 为色谱柱 ,以甲醇 -水 -磷酸 (250∶250∶0 2)为流动相 ,检测波长为254nm。结果 :血浆中阿魏酸钠浓度在1 2～24μg/ml范围内线性关系良好 ,回归方程为 :Y=4 6749×10-5X +0 03628(r=0 9993) ,平均回收率为 (98 8±0 6) % ,高、中、低3种浓度日内、日间精密度小于10 %。结论 :本方法灵敏、准确 ,可对血浆中阿魏酸钠进行测定。
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| 关 键 词： | 阿魏酸钠 高效液相色谱法 血药浓度 |
| 文章编号： | 1001-0408(2003)01-0033-02 |
| 修稿时间： | 2002年1月25日 |
Determination of the Level of Sodium Ferulate in Plasma by HPLC |
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| REN Zhiqiang,LIU Lijun,LONG Aibing,LI Xianwei.Determination of the Level of Sodium Ferulate in Plasma by HPLC[J].China Pharmacy,2003,14(1):33-34. |
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| Authors: | REN Zhiqiang LIU Lijun LONG Aibing LI Xianwei |
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| Abstract: | OBJECTIVE:A HPLC method was established for determination of the level of sodium ferulate in plasma.ME_THODS:A C18 radial compression column was used with a mobile phase of CH3OH∶H2O∶H3PO4(250∶250∶0.2).The detecing wavelength was 254nm.RESULTS:The linear range was 1.2～24μg/ml(r=0.9 993).The average recovery was(98.8±0.6)%.The RSDs of within-day and between-day were less than 10%.CONCLUSION:This method provides an accurate and sensitive way in detecting plasma concentration of sodium ferulate. |
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| Keywords: | sodium ferulate HPLC blood drug concentration |
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