左氧氟沙星注射液致静脉炎因素分析

目的探讨左氧氟沙星注射液致静脉炎的因素。方法将900例左氧氟沙星静脉滴注患者随机分为9组,每组100例。即药物不同浓度组:0.2mg加100ml液体组、0.2mg加150ml液体组、0.2mg加200ml液体组;液体不同温度组:35℃组、30℃组、20℃组;不同滴速组:51～60滴/min组、41～50滴/min组、31～40滴/min组。并将每项因素带入多元线性回归方程,计算与静脉炎发生的关系。结果左氧氟沙星0.2mg加100ml液体、51～60滴/min、20℃的液体与静脉炎的发生呈正相关,上述3种情况下左氧氟沙星注射液易引发静脉炎的发生。结论左氧氟沙星静脉滴注时注意药物浓度、滴速和液体的温度,可防止静脉炎的发生。

Factor analysis of levofloxacin led phlebitis

Objective To discuss the factor of levofloxacin led phlebitis.Methods 900 cases patients of intravenous drip levofloxacin were randomly divided into 9 groups（each of 100 cases）,the levofloxacin 0.2mg＋100ml liquid、levofloxacin 0.2mg＋150ml liquid and levofloxacin 0.2mg＋200ml liquid group and 51～60 drops/min、41～50 drops/min and 31～40 drips/min,35、30、20℃ group.Each groups and each factor were taken into concideration.Results The factor of levofloxacin 0.2mg＋100ml liquid、51～60 drops/min and 20℃ were positively correlated with phlebitis.Conclusion The attention of levofloxacin intravenous drug concentration,dropping speed and temperature of the liquid to prevent phlebitis.