地塞米松治疗感染性脑水肿的临床观察

目的:探索治疗小儿感染性脑水肿的有效方法。方法:87例感染性脑水肿病儿随机分为两组,治疗组44例应用地塞米松加甘露醇治疗,对照组43例应用速尿加甘露醇治疗。采用Elisa法、Griess法检测两组病儿治疗前后脑脊液肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、一氧化氮(NO)的水平,比较两组病儿的临床疗效、死亡率及后遗症发生率。结果:①治疗后治疗组病儿脑脊液TNF-α、IL-1及NO水平低于对照组,差异显著(P<0.05)。②治疗组的临床疗效优于对照组,差异显著(P<0.05)。③治疗组的死亡率及后遗症发生率低于对照组,差异显著(P<0.05)。结论:地塞米松是治疗感染性脑水肿的最有效药物,地塞米松与甘露醇联用可作为治疗感染性脑水肿的首选方案。

Clinical observation of dexamethasone used in treatment of infective brain edema

Objective:To probe into the effective therapy of treating infective brain edema.Methods:87 cases of infective brain edema were divided into two groups, 44 cases of treatment group were treated with dexamethasone and mannitol, 43 cases of control group were treated with lasix and mannitol.The levels of TNF-α, IL-1, NO of CSF were determined in two group by ELISA method and Griess method to compare the curative effect, mortality and sequelae rate in two groups.Results:①The levels of TNF-α, IL-1, NO of treatment group were significantly lower than those of control group (P<0.05);②The curative effect of treatment group was significantly better than that of control group (P<0.05);③The mortality and sequelae rate of treatment group were significantly lower than that of control group (P<0.05).Conclusion:Dexamethasone was effective drug of infective brain edema of choice, and dexamethasone united mannitol could be regimen of choice.