| 鹿茸多肽的纯化和鉴定(英文) |
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| 引用本文： | 张志强,张沅,王本祥,周海欧,王岩,张宏.鹿茸多肽的纯化和鉴定(英文)[J].药学学报,1992,27(5):321-324. |
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| 作者姓名： | 张志强 张沅 王本祥 周海欧 王岩 张宏 |
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| 作者单位： | 吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室，吉林省中医中药研究院中药所药理室 长春 130021，长春 130021，长春 130021，长春 130021，长春 130021，长春 130021 |
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| 摘 要： | 应用凝胶过虑和离子交换层析等技术,从鹿茸(pilose antler or Cervus nipponTemminck)中分离纯化出一种多肽(peptide of pilose antler,PAP)。经高效液相色谱和N-末端氨基酸分析鉴定为单一多肽,氨基酸组成分析证明,PAP是由68个氨基酸组成,分子是为7200。药理研究证明,PAP对大鼠角叉菜胶性足肿胀具有明显的抑制作用并呈现良好的量—效关系。
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| 关 键 词： | 鹿茸 多肽 抗炎作用 |
| 收稿时间： | 1991-05-17 |
PURIFICATION AND PARTIAL CHARACTERIZATION OF ANTI-INFLAMMATORY PEPTIDE FROM PILOSE ANTLER OF CERVUS NIPPON TEMMINCK |
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| ZQ Zhang,Y Zhang,BX Wang,HO Zhou,Y Wang,H Zhang.PURIFICATION AND PARTIAL CHARACTERIZATION OF ANTI-INFLAMMATORY PEPTIDE FROM PILOSE ANTLER OF CERVUS NIPPON TEMMINCK[J].Acta Pharmaceutica Sinica,1992,27(5):321-324. |
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| Authors: | ZQ Zhang Y Zhang BX Wang HO Zhou Y Wang H Zhang |
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| Institution: | Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun. |
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| Abstract: | An anti- inflammatory compound was purified and isolated from pilose ant-ler of Cervus nippon Temminck by dialysis, gel filtration and ion-exchange chromatographytechniques. HPLC and N-terminal amion acid analysis identified the compound as a homoge-neous peptide.The peptide is composed of 68 amino acids and its molecular weight,as determinedby amino analysis, is about 7200. |
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| Keywords: | Pilose antler Peptide Anti--inflammatory action |
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