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| 抑癌基因P53及其蛋白产物表达与膀胱癌发生及病理关系 | |
| 引用本文： | 吴明明 邹文. 抑癌基因P53及其蛋白产物表达与膀胱癌发生及病理关系[J]. 中华泌尿外科杂志, 1994, 15(6): 412-414 |
| 作者姓名： | 吴明明 邹文 |
| 作者单位： | 天津医科大学总医院泌尿外科，湖南医科大学附属第二医院泌尿外科 |
| 基金项目： | 国家自然科学基金,天津市21世纪青年科学基金 |
| 摘 要： | 以光敏生物素－金标链亲和素核酸原位杂交及免疫组化方法检测膀胱癌病理标本中Ｐ５３基因片段及其蛋白表达。１３例原位杂交阳性膀胱癌中，Ｐ５３蛋白表达阳性率５３．９％，提示约半数膀胱癌的发生可能与Ｐ５３基因突变有关；Ｐ５３蛋白表达与病理分级、临床分期无明显关系。 |
| 关 键 词： | 膀胱肿瘤，癌，免疫组织化学，基因 |
Expression of suppressor gene P53 and carcinogenesis of bladder cancer |
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| Wu Ming-ming, Ma Hong-shun, Yu Song-ting, et al. Expression of suppressor gene P53 and carcinogenesis of bladder cancer[J]. Chinese Journal of Urology, 1994, 15(6): 412-414 | |
| Authors: | Wu Ming-ming Ma Hong-shun Yu Song-ting et al |
| Abstract: | With nucleic acid in situ hybridization and immunohistochemical methods, the p53 gene fragment and its protein expression were determined.In 13 cases of bladder tumor showing positive results with in situ hybridization, the expression of the P53 protein is detected in 53.9%. The results suggested that in about 50%of bladder cancers, mutation of the suppressor gene P53 was associated with carcinogenesis. No positive correlation between the pathologic grading and clinical staging with the expression of the protein has been noted. |
| Keywords: | Bladder neoplsmas Carcinoma Immunochemistry genes |
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