快速姑息放疗联合化疗治疗鼻咽癌远处转移

目的：探讨鼻咽癌（NPC）远处转移综合治疗的效果及预后因素。方法：对38NPC放疗后远处转移的病例采用快速姑息放疗以及DDP＋5－Fu为主的全身化疗。单纯肝转移病例以介入化疗为主。结果：止痛有效率87％，全组中位生存期9个月，（1年内死亡19例，5例生存期达2年）；现存活5例，其生存期为7个月－15个月。结论：采用快速姑息放疗联合以DDP＋5－Fu为主的全身化疗，治疗NPC远处转移取得一定效果。KPS评分、出现转移的早晚、单／多器官转移及化疗疗程是影响预后的主要因素。

Rapid palliative radiotherapy combined with chemotherapy for treating distant metastases of nasopharyngeal carcinoma

Objective:To evaluate the efficiency of rapid palliative radiotherapy combined with chemothrapy for metastases of nasopharyngeal carcinoma (NPC)and its effect on prognosis.Methods:38 NPC patients with long distant metastases after radical radiotherapy were reviewed.They received palliative radiotherapy and chemotherapy with cisplatin and 5 fluorouracil.The total doses of irradiation was 30Gy/10F/2W.Interventional chemotherapy as a main regimen was used to treat patients with liver metastases.Results:The effective control rate of pain was 87%.The overall median survival time was 9 months.Conclusions:Rapid palliative radiotherapy combined with chemotherapy may be an effective treatment for long distant metastases tumors of NPC.Karnofsky performance status (KPS),time of metastasis,single/multiple organ involved and courses of chemothrapy are important factors for prognosis.