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甲状腺功能亢进大鼠肝脏抗氧化能力的变化
引用本文:刘颖,王秀丽,杜卫,徐宏伟,潘晓亮,李玲,吴梅,于向民. 甲状腺功能亢进大鼠肝脏抗氧化能力的变化[J]. 青岛大学医学院学报, 2007, 43(1): 74-75
作者姓名:刘颖  王秀丽  杜卫  徐宏伟  潘晓亮  李玲  吴梅  于向民
作者单位:青岛大学医学院生物化学与分子生物学教研室,山东,青岛,266021;青岛大学医学院组织学与胚胎学教研室,山东,青岛,266021
摘    要:目的探讨甲状腺功能亢进(甲亢)大鼠肝脏的抗氧化能力。方法建立甲亢大鼠模型,采用酶法测定甲亢组和正常组大鼠肝脏匀浆中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPX)的活性及丙二醛(MDA)的含量。结果甲亢组大鼠肝脏SOD和GPX活性与正常组比较明显降低(t=2.38,P<0.05;t=4.41,P<0.01),而MDA含量则明显升高(t=6.34,P<0.01)。结论甲亢大鼠肝脏抗氧化能力明显下降。

关 键 词:甲状腺功能亢进症    抗氧化  大鼠  Wistar
文章编号:1672-4488(2007)01-0074-02
收稿时间:2006-03-29
修稿时间:2006-11-10

CHANGES IN HEPATIC ANTIOXIDATION ACTION IN RATS WITH HYPERTHYROIDISM
LIU YING, WANG XIU-LI, DU WEI, et al. CHANGES IN HEPATIC ANTIOXIDATION ACTION IN RATS WITH HYPERTHYROIDISM[J]. Acta Academiae Medicinae Qingdao Universitatis, 2007, 43(1): 74-75
Authors:LIU YING   WANG XIU-LI   DU WEI   et al
Abstract:ObjectiveTo study the antioxidation action in the liver of rats with hyperthyroidism.MethodsAn animal model of rat with hyperthyroidism was established and hepatic SOD,MDA and GPX were detected by enzymology method. ResultsThe content of SOD and GPX of hyperthyroidism group was significantly lower than that of the normal group(t=2.38,P<0.05;t=4.41,P<0.01),while the content of MDA of hyperthyroidism group was significantly higher than that of the normal group(t=6.34,P<0.01).ConclusionThe antioxidation action of the liver decreased significantly in rats with hyperthyroidism.
Keywords:hyperthyroidism   liver   antioxidation   rats, Wistar
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