2型糖尿病血管病变患者血小板相关参数的变化

目的 探讨血小板相关参数在2型糖尿病患者中的改变及临床意义.方法 选取128例2型糖尿病住院患者,根据患者是否出现血管病变分为血管病变组（49例）和无血管病变组（79例）,分别检测各组的血小板计数（PLT）、平均血小板体积（MPV）、平均血小板分布宽度（PDW）和大血小板（L-PLT）,并与50例健康体检者（对照组）进行比较分析.结果 血管病变组患者MPV、PDW和L-PLT较无血管病变组增高[（13.98±2.35） fl比（11.53±2.06）n、（15.87±2.18）n比（13.51±2.01） fl、（10.91±1.34）×109/L比（8.72±1.03）×109/L],PLT较无血管病变组降低[（115.2±10.5）×109/L比（129.6±8.7）×109/L],差异均有统计学意义（P＜0.05）.血管病变组MPV、PDW、L-PLT、PLT与对照组[（10.41±1.95）n、（11.15±1.88）n、（6.21±0.98）×109/L、（176.5±7.2）×109/L]比较差异有统计学意义（P＜0.05）.结论 血小板相关参数检测有助于糖尿病血管病变的临床诊断,对疾病的临床诊疗和病情监测有重要意义.

The changes of platelet parameters in type 2 diabetic patients with vascular complications

Objective To investigate the changes ofplatelet parameters in type 2 diabetic patients with vascular complications.Methods One hundred and twenty-eight cases of type 2 diabetic patients were selected and divided into vascular disease group （49 cases） and non-vascular disease group （79 cases）.Platelet count （PLT）,mean platelet volume （MPV）,mean platelet distribution width （PDW） and large-platelet （L-PLT） was detected,meanwhile 50 healthy volunteers were as control group.Results The MPV,PDW and L-PLT in vascular disease group was significantly higher than that in non-vascular disease group and control group [（13.98-2.35） fl vs.（11.53 ±2.06）,（10.41 ± 1.95） fl; （15.87 ±2.18） fl vs.（13.51 ± 2.01）,（11.15 ± 1.88） fl; （10.91 ± 1.34） × 109/L vs.（8.72 ± 1.03） × 109/L,（6.21 ± 0.98） × 109/L] （P ＜ 0.05）,and PLT in vascular disease group was significantly lower than that in non-vascular disease group and control group [（115.2 ± 10.5） × 109/L vs.（129.6 ± 8.7） × 109/L,（176.5 ± 7.2） × 109/L] （P ＜ 0.05）.Conclusion Platelet parameters detection are helpful for clinical diagnosis of diabetic angiopathy and play an important role in clinical diagnosis and disease monitoring.