艾塞那肽对大鼠脑缺血再灌注损伤的保护作用研究

目的 研究艾塞那肽对大鼠脑缺血再灌注损伤的保护作用。方法 60只Wistar大鼠经线栓法建立大鼠大脑缺血再灌注动脉模型,随机分为艾塞那肽组(n=30)和生理盐水组(n=30),再灌注后60min给药,比较两组再灌注后24h的Bederson评分、梗死灶体积、超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)等指标。结果 艾塞那肽组大鼠再灌注24h后Bederson评分、梗死灶体积、SOD水平较生理盐水组显著下降(P<0.05),VEGF水平较生理盐水组显著升高(P<0.05)。结论 艾塞那肽对大鼠脑缺血再灌注损伤有神经保护作用。

Neuroprotective Effects of Exenatide for Cerebral Ischemia Reperfusion Injury of Rats

Objective To investigate the neuroprotective effects of exenatide for cerebral ischemia reperfusion injury of rats. Methods Sixty Wistar rats were built a stroke and reperfusion model by suture method, At one hour after reperfusion, exenatide(n=30) or saline(n=30) was administered intraperitoneally. Bederson's test, infarct volumes, superoxide dismutase(SOD) and vascular endothelial growth factor (VEGF) were measured. Results The Bederson's scores, infarct volumes and SOD of exenatide-treated rats were significantly decreased than those of control rats(P<0.05). VEGF level of exenatide-treated rats was significantly increased, compared to that of control rats. Conclusion Exenatide has the neuroprotective effects for cerebral ischemia reperfusion injury of rats.