| 葛根口服液的工艺研究及葛根素的测定 |
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| 引用本文： | 罗琥捷,雷晓林,陈祥吉. 葛根口服液的工艺研究及葛根素的测定[J]. 安徽医药, 2008, 12(10): 902-904 |
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| 作者姓名： | 罗琥捷 雷晓林 陈祥吉 |
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| 作者单位： | 东方药林药业有限公司南方医科大学产学研结合基地,广东,广州,510515;东方药林药业有限公司南方医科大学产学研结合基地,广东,广州,510515;东方药林药业有限公司南方医科大学产学研结合基地,广东,广州,510515 |
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| 摘 要： | 目的对以葛根素为功效／指标性成分的嘲艮液进行工艺研究及其含量测定。方法口服液考察提取和精制工艺，含测采用HPLC。结果水提提取率可达90％，正交试验优选最佳提取条件为：固液比为1：8，提取次数2次，每次提取时间为2ho醇沉、壳聚糖澄清效果优于明胶和ZTC1＋1。HPLC测定中前处理操作简便。结论葛根口服液水提、精制工艺可满足要求，稳定。
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| 关 键 词： | 葛根素 口服液 工艺 含量测定 HPLC |
Preparation technology of oral liquid containing radix puerariae lobatae and determination of puerarin |
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| LUO Hu-jie,LEI Xiao-lin,CHEN Xiang-ji. Preparation technology of oral liquid containing radix puerariae lobatae and determination of puerarin[J]. Anhui Medical and Pharmaceutical Journal, 2008, 12(10): 902-904 |
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| Authors: | LUO Hu-jie LEI Xiao-lin CHEN Xiang-ji |
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| Affiliation: | (Orient Pharmaceutical Co. Ltd, Obstetrics Research Base of Southern Medical University, Guangzhou 510515 China ) |
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| Abstract: | Aim To study the technology of oral liquid containing puerarin as the virtue or symbol component. Method The puerarin was determinated by HPLC. The technology of oral liquid contained extracting and refining. Result The extracting by water was 90% L^9 （3^4 ） was used. The results showed that the rate of raw material and solvent was 1 ： 8, extracting times was twice and extracting time was 2 h. The clarifing effect by use of Chitosan and ethanol is better than that by use of glutin and ZTC 1 ＋ 1. The handling before HPLC was easy. Conclusion The technology of oral liquid containing puerarin consists of extracting by water and refining by Chitosan or ethanol and is steady. |
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| Keywords: | HPLC |
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