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| 非化疗药物引起的粒细胞缺乏及其干预 | |
| 引用本文： | 张觅,程虹,刘巍,蒋巧俐,吴东方. 非化疗药物引起的粒细胞缺乏及其干预[J]. 药物流行病学杂志, 2015, 0(4): 246-249 |
| 作者姓名： | 张觅 程虹 刘巍 蒋巧俐 吴东方 |
| 作者单位： | 武汉大学中南医院药学部 (武汉 430071);武汉大学中南医院药学部 (武汉 430071);武汉大学中南医院药学部 (武汉 430071);武汉大学中南医院药学部 (武汉 430071);武汉大学中南医院药学部 (武汉 430071) |
| 摘 要： | 摘 要几乎所有类型的临床药物都可引起粒细胞缺乏（drug induced agranulocytosis, DIA）。虽然药物导致的DIA比较罕见，但其死亡率可高达5%。由于DIA常常可引起严重的脓毒症、深部组织感染、败血症和感染性休克，所以被认为是潜在的严重不良事件。通过查阅文献，本文综述了DIA的流行病学、病理机制、诊断、预后影响因素、临床症状、干预措施和常见的DIA药物。 |
| 关 键 词： | 中性粒细胞缺乏；中性粒细胞减少；药物不良反应；造血生长因子 |
Non chemotherapy Drug induced Agranulocytosis and its Management |
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| Zhang Mi,Cheng Hong,Liu Wei,Jiang Qiaoli and Wu Dongfang. Non chemotherapy Drug induced Agranulocytosis and its Management[J]. Chinese Journal of Pharmacoepidemiology, 2015, 0(4): 246-249 | |
| Authors: | Zhang Mi Cheng Hong Liu Wei Jiang Qiaoli Wu Dongfang |
| Affiliation: | Department of pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Department of pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Department of pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Department of pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China;Department of pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China |
| Abstract: | ABSTRACT Almost all classes of drugs can cause agranulocytosis. DIA is rare, but the mortality can be as high as 5%. DIA is considered to be potentially serious adverse events, for it can cause severe sepsis, deep tissue infection, sepsis and septic shock. This paper over viewed the incidence, mortality, pathogenesis, diagnosis, prognostic factors, clinical presentation and intervention of DIA and the common DIA drugs. |
| Keywords: | Agranulocytosis Neutropenia Drug induced agranulocytosis Hematopoietic growth factor |