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| 肿瘤辐射增敏的分子机制 | |
| 引用本文： | 顾菲,刘晓秋. 肿瘤辐射增敏的分子机制[J]. 国际放射医学核医学杂志, 2006, 30(5): 298-301 |
| 作者姓名： | 顾菲 刘晓秋 |
| 作者单位： | 300192 天津, 中国医学科学院中国协和医科大学放射医学研究所生物研究室 |
| 摘 要： | 关于肿瘤辐射增敏的分子机制研究主要包括:DNA损伤的加重及其修复抑制,改变细胞氧合状态,控制细胞周期,转入凋亡相关基因,导入反义物等。不同的辐射增敏剂可通过不同的分子机制提高肿瘤辐射敏感性。分子机制研究将为开发出更高效的辐射增敏剂提供理论依据。 |
| 关 键 词： | 辐射增敏药 细胞低氧 DNA损伤 基因疗法 |
| 文章编号： | 1673-4114(2006)05-0298-04 |
| 收稿时间： | 2006-05-29 |
| 修稿时间： | 2006-05-29 |
The molecular mechanism of tumor radiosensitizer |
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| GU Fei,LIU Xiao-qiu. The molecular mechanism of tumor radiosensitizer[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2006, 30(5): 298-301 | |
| Authors: | GU Fei LIU Xiao-qiu |
| Affiliation: | Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China |
| Abstract: | The study of molecular mechanism of tumor radiesensitizer at home and abroad includes:DNA damage and its repair inhibition,change the oxygen content in tumor cells,control cell cycle,induct cell apoptosis correlative gene and so on.Different radiosensitizing agents play its effort in different ways.The study of molecule mechanism will provide academic basis for discovering new radiosensitizing agents which with higher sensitizing effort. |
| Keywords: | Radiosensitizing agents Cell hypoxia DNA damage Gene therapy |
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