| 苄基四氢巴马汀对心肌动作电位及浦氏纤维跨膜钾... |
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| 引用本文： | 曾维忠 夏国瑾. 苄基四氢巴马汀对心肌动作电位及浦氏纤维跨膜钾...[J]. 中国药理学报, 1990, 11(4): 314-317 |
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| 作者姓名： | 曾维忠 夏国瑾 |
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| 摘 要： |
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| 关 键 词： | 苄基四氢 巴马汀 心肌 电生理学 |
Effects of benzyltetrahydropalmatine on action potentials of myocardium and transmembrane K+ and Ca2+ currents in Purkinje fibers |
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| W Z Zeng,G J Xia,W X Yao,X G Zong,M X Jiang. Effects of benzyltetrahydropalmatine on action potentials of myocardium and transmembrane K+ and Ca2+ currents in Purkinje fibers[J]. Acta Pharmacologica Sinica, 1990, 11(4): 314-317 |
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| Authors: | W Z Zeng G J Xia W X Yao X G Zong M X Jiang |
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| Affiliation: | Department of Pharmacology, Tongji Medical University, Hankou, China. |
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| Abstract: | Standard microelectrode and two-microelectrode voltage clamp techniques were used to study the effects of benzyltetrahydropalmatine (BTHP) on action potentials of isolated myocardium and transmembrane K+ and Ca2+ currents in Purkinje fibers. The effect of BTHP 3-100 mumol/L consisted of prolongation of the action potential duration and reduction of delayed rectifier current (Ik) in concentration-dependent manner. At concentration above 200 mumol/L, the contractile force of the isolated myocardium was depressed and in voltage clamp experiments the slow inward current (Isi) was reduced. These results suggest that the inhibition of Ik induced by BTHP was in relation to its anti-arrhythmic action. |
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