Anterior mediastinal immature teratoma with precocious puberty in a child with Klinefelter syndrome. |
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Authors: | Pen-Hua Su Shi-Ping Luh Da-Mien Yieh Jia-Yuh Chen Suh-Jen Chen Huei-Mei Hung Pei-Fen Liao |
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Affiliation: | Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan. |
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Abstract: | ABSTRACT: Klinefelter syndrome occurs in approximately 1 in 1000 males. A 4-year-old boy presented with precocious puberty and an anterior mediastinal mass. Serum alpha-fetoprotein and human chorionic gonadotropin levels were mildly increased. Computed tomography revealed a germ cell tumor (GCT) of the mediastinum. Complete resection of the tumor was performed. Histologic analysis revealed an immature teratoma. Males with Klinefelter syndrome develop GCTs at a rate 50 times higher than unaffected males. This case report calls attention to the need to rule out Klinefelter syndrome in boys who present with precocious puberty and a mediastinal GCT. |
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