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| 胆固醇酯转运蛋白TaqIB和亚甲基四氢叶酸还原酶MTHFR C667T基因多态性与视网膜中央静脉阻塞的关系 | |
| 引用本文： | 王小东,张德秀. 胆固醇酯转运蛋白TaqIB和亚甲基四氢叶酸还原酶MTHFR C667T基因多态性与视网膜中央静脉阻塞的关系[J]. 陕西医学杂志, 2011, 40(10): 1352-1354 |
| 作者姓名： | 王小东 张德秀 |
| 作者单位： | 1. 西安市第一医院,西安,710002 2. 西安交通大学医学院第一附属医院 |
| 摘 要： | 目的:探讨胆固醇酯转运蛋白(CETP)基因TaqIB和N5 N10-亚甲基四氢叶酸还原酶(MTHFR)基因MTHFR C667T多态性与视网膜中央静脉阻塞的关系。方法:采用多聚酶链反应-限制性内切酶片段长度多态性(PCR-RFLP)技术检测60例经视网膜荧光造影诊断的视网膜中央静脉阻塞患者和120例对照者的CETP和MTHFR基因多态性。结果:视网膜中央静脉阻塞组B1/B1基因型频率(33.3%)明显高于对照组(12.5%)(P<0.05),B1等位基因频率(51.8%)也明显高于对照组(31.8%)(P<0.05);视网膜中央静脉阻塞组T/T基因频率(30.0%)明显高于对照组(15.0%)(P<0.05),T等位基因频率(50.6%)也明显高于对照组(34.6%)(P<0.05);TaqIB基因的B1等位基因与MTHFR基因的T等位基因之间有协同作用(rs=0.954)。结论:CETP与MTHFR基因和视网膜中央静脉阻塞的发病有关,CETP和MTHFR基因之间有协同作用。 |
| 关 键 词： | 视网膜静脉闭塞 胆固醇酯类 亚甲基四氢叶酸还原酶 基因多态性 |
The association of the cholesteryl ester transfer protein TaqIB and methylenetetrahydrofolate reductase C667T polymorphism with central retinal vein occlusion |
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| Wang Xiaodong,Zhang Dexiu. The association of the cholesteryl ester transfer protein TaqIB and methylenetetrahydrofolate reductase C667T polymorphism with central retinal vein occlusion[J]. Shaanxi Medical Journal, 2011, 40(10): 1352-1354 | |
| Authors: | Wang Xiaodong Zhang Dexiu |
| Affiliation: | Xi'an NO.1 Hospital(Xi'an 710002) Wang Xiaodong Zhang Dexiu |
| Abstract: | Objective:To investigate the association of the cholesteryl ester transfer protein(CETP) TaqIB and methylenetetrahydrofolate reductase(MTHFR) C667T polymorphism with central retinal vein occlusion(CRVO).Methods:The CETP TaqIB and MTHFR C667T gene genotypes were determined in 60 CRVO patients who were diagnosed by retinal fluorescence angiography and 120 subjects without CRVO by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results:CRVO group B1/B1 genotype frequency(33.3%) was... |
| Keywords: | Retinal vein occlusion Cholesterol esters Methylenetetrahydrofolate reductase Genepolymorphism |
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