| 常见植物药对结肠癌的防治作用及其作用机制 |
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| 引用本文： | 周慧萍,李宇华,王宇晖,苏义龙,杨营营,徐笑天,段小群.常见植物药对结肠癌的防治作用及其作用机制[J].国际肿瘤学杂志,2020(1):51-55. |
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| 作者姓名： | 周慧萍 李宇华 王宇晖 苏义龙 杨营营 徐笑天 段小群 |
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| 作者单位： | 桂林医学院药学院;南部战区海军第一医院药剂科 |
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| 摘 要： | 植物药对结肠癌具有良好的防治作用。姜黄素、多糖(苹果多糖、香菇多糖)、皂苷(重楼皂苷、人参皂苷)、白藜芦醇、槲皮素等植物药可通过不同信号通路抑制结肠癌细胞的增殖,促进细胞凋亡。此外,植物药还具有抗炎、抗氧化、抗血管生成、减轻化疗药物不良反应、逆转肿瘤细胞耐药等作用。了解植物药对结肠癌的防治作用及其可能的作用机制,能为结肠癌的临床防治提供更多的理论依据及治疗思路。
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| 关 键 词： | 植物药 结肠肿瘤 药理作用 分子作用机制 |
Preventive and therapeutic effects of common plant drugs on colon cancer and its mechanism |
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| Zhou Huiping,Li Yuhua,Wang Yuhui,Su Yilong,Yang Yingying,Xu Xiaotian,Duan Xiaoqun.Preventive and therapeutic effects of common plant drugs on colon cancer and its mechanism[J].Journal of International Oncology,2020(1):51-55. |
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| Authors: | Zhou Huiping Li Yuhua Wang Yuhui Su Yilong Yang Yingying Xu Xiaotian Duan Xiaoqun |
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| Institution: | (Pharmacy School of Guilin Medical University,Guilin 541004,China;Department of Pharmacy,First Naval Hospital of Southern Theater Command,Zhanjiang 524005,China) |
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| Abstract: | It is shown that phytochemicals have a protective effect on colon cancer.Curcumin,polysaccharides(apple polysaccharides,mushroom glucans),saponins(paridis saponins,ginsenosides),resveratrol,quercetin and other plant drugs can inhibit colon cancer cell proliferation and promote cell apoptosis through different signaling pathways.In addition,it also has anti-inflammatory,antioxidant,anti-angiogenesis,reduce the toxic side effects of chemotherapy drugs,and reverse the drug resistance of tumor cells.Understan-ding the prevention and cure effect of plant medicine on colon cancer and its possible mechanism can provide more theoretical basis and therapeutic ideas for the clinical prevention and cure of colon cancer. |
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| Keywords: | Herbal drugs Colonic neoplasms Pharmacological action Molecular mechanisms |
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