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| 血清淀粉样蛋白A促进动脉粥样硬化形成机制研究进展 | |
| 引用本文： | 夏可心,刘海霞. 血清淀粉样蛋白A促进动脉粥样硬化形成机制研究进展[J]. 中国动脉硬化杂志, 2021, 29(10): 913-916 |
| 作者姓名： | 夏可心 刘海霞 |
| 作者单位： | 哈尔滨医科大学附属第二医院心内科,黑龙江省哈尔滨市 150001 |
| 基金项目： | 教育部“春晖计划”合作科研项目(HLJ2019026) |
| 摘 要： | 血清淀粉样蛋白A作为急性反应时相蛋白在动脉粥样硬化的形成过程中有明显的促进作用。血清淀粉样蛋白A通过刺激炎症因子的释放导致炎症的产生,与脂蛋白结合改变高密度脂蛋白的生理功能,引发血管内皮和平滑肌功能障碍,还会引起血栓形成,这些都促进动脉粥样硬化的发生发展。 |
| 关 键 词： | 血清淀粉样蛋白A 动脉粥样硬化 炎症 高密度脂蛋白功能 血管壁功能 |
| 收稿时间： | 2020-11-26 |
| 修稿时间： | 2021-04-02 |
Research progress on the mechanism of serum amyloid A promoting atherosclerosis |
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| XIA Kexin,LIU Haixia. Research progress on the mechanism of serum amyloid A promoting atherosclerosis[J]. Chinese Journal of Arteriosclerosis, 2021, 29(10): 913-916 | |
| Authors: | XIA Kexin LIU Haixia |
| Affiliation: | Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China |
| Abstract: | Serum amyloid A has a significant effect on the formation of atherosclerosis as an acute reaction, leading to inflammation by stimulating the release of inflammation factors. It is vital for atherosclerosis that serum amyloid A combined with lipoprotein changes the physiological function of high density lipoprotein. Serum amyloid A can affect the function of vascular endothelium and smooth muscle, and also cause thrombosis,which all promote the development of atherosclerosis. |
| Keywords: | serum amyloid A atherosclerosis inflammation high density lipoprotein function vascular wall function |
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