Diagnostic and prognostic significance of chromosome abnormalities in acute nonlymphocytic leukemia |
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Authors: | Harvey M. Golomb |
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Affiliation: | Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois USA |
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Abstract: | Chromosome abnormalities in acute nonlymphocytic leukemia (ANLL) are of diagnostic and prognostic importance. The presence of an abnormality in ANLL patients predicts an unfavorable course; the prediction is particularly significant for acute myelocytic leukemia. The occurrence of a t(15;17) assists in the diagnosis of “microgranular” acute promyelocytic leukemia; transmission electron microscopy can aid in confirming this diagnosis. The presence of a chromosome abnormality in previously treated malignant lymphoma patients with undiagnosed cytopenia supports a diagnosis of preleukemia. The presence of a chromosome abnormality in patients with the hypereosinophilic syndrome might identify the subset of patients who have a neoplastic disease. |
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Keywords: | Address requests for reprints to: Harvey M. Golomb M.D. 950 East 59th Street Box 420 Chicago IL 60637. |
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