脉压与冠心病危险性的相关性研究

目的探讨脉压与冠心病危险性的关系。方法242例入院诊断为冠心病的患者,其中男性107例,女性135例,年龄38-80(58.4±9.2)岁。测量外周肱动脉压力计算脉压,并行冠状动脉造影术。冠状动脉病变的严重程度用冠状动脉病变的血管支数表示,分析脉压与冠状动脉病变的相关性。结果 与脉压<65 mmHg的患者相比,脉压≥65 mmHg患者冠状动脉3支血管病变的患病率显著增高(27.8％比12.6％,P<0.05),冠心病、心肌梗死、心力衰竭的发生率显著增高(P均<0.05)。结论 脉压是冠心病的一个重要和独立的相关因素,脉压增高可作为全身心血管病的一个危险信号,指导早期干预。

Relationship between pulse pressure and incidence of coronary heart disease

Objective To evaluate the relation of the pulse pressure(PP) to the incidence of coronary heart disease. Methods Two hundred forty-two patients with coronary heart disease were diagnosed when they admitted, 107male patients, 135 female patients , mean age 38 - 80 (58. 4 ± 9. 2) years. Brachial systolic and diastolic blood pressure were measured. The severity of coronary heart disease was shown as the number of lesion arteries. Results Compared to patients with PP<65mmHg,patients with PP≥65mmHg had higher incidence of 3 lesion branches of coronary artery(27. 8% vs 12. 6% ,P<0. 05),and they had higher incidence of coronary heart disease,myocardial infarction and heart failure(F<0. 05). Conclusion PP may be an independent and important risk factor for coronary heart disease. This parameter could be a marker of cardiovascular risk,instructing early intervention.