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| 逐步代入勾兑法考察中药饮片质量稳定性 | |
| 引用本文： | 梅新路,肖慧,章军,饶毅,魏慧珍,王跃生.逐步代入勾兑法考察中药饮片质量稳定性[J].中国实验方剂学杂志,2013,19(18):55-57. |
| 作者姓名： | 梅新路 肖慧 章军 饶毅 魏慧珍 王跃生 |
| 作者单位： | 1. 中国中医科学院中药研究所,北京 100700;江西中医学院,南昌 330004 2. 中国中医科学院中药研究所,北京,100700 3. 江西中医学院,南昌,330004 4. 中国中医科学院中药研究所,北京 100700;湖南中医药大学,长沙 410208 |
| 基金项目： | 国家重点基础研究发展计划"973"项目(项目编号：2010CB530600)中医药行业科技专项(项目编号：201307009) |
| 摘 要： | 目的:采用逐步代入勾兑法控制中药饮片的质量稳定性.方法:选取黄芩为研究对象,以黄芩苷、黄芩素和汉黄芩素为指标成分,采用逐步代入法勾兑,对比勾兑前后各批饮片中指标成分含量与目标饮片的相对标准偏差和指纹图谱相似度差异.结果:勾兑饮片中各指标成分含量与目标饮片的RSD ＜5％,勾兑饮片与目标饮片HPLC指纹图谱相似度0.986.结论:不同批次饮片通过逐步代入法勾兑可使指标成分含量的RSD降低和指纹图谱相似度趋于一致,显著提高药材的质量均一性.该方法准确度高、操作简便,不使用复杂数学软件,可作为中药饮片勾兑的新方法. |
| 关 键 词： | 逐步代入法 勾兑 黄芩 指纹图谱 高效液相色谱法 |
| 收稿时间： | 2013/1/25 0:00:00 |
Investigation of Quality Stability of Chinese Medicine Pieces by Stepwise Blending Method |
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| MEI Xin-lu,XIAO Hui,ZHANG Jun,RAO Yi,WEI Hui-zhen and WANG Yue-sheng.Investigation of Quality Stability of Chinese Medicine Pieces by Stepwise Blending Method[J].China Journal of Experimental Traditional Medical Formulae,2013,19(18):55-57. | |
| Authors: | MEI Xin-lu XIAO Hui ZHANG Jun RAO Yi WEI Hui-zhen and WANG Yue-sheng |
| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Hunan University of Chinese Medicine, Changsha 410208, China |
| Abstract: | Objective: To control quality stability of Chinese materia medica pieces by stepwise blending method. Method: Scutellariae Radix was chosen as research object,with the contents of baicalin,baicalein and wogonin as indexes,five batches of Scutellariae Radix were blended to get one target cruse drug using stepwise blending method,fingerprint similarity was used to verity quality consistency of Scutellariae Radix. Result: RSD of the contents of index components between blending pieces and objective piece was less than 5%,fingerprint similarity between blending pieces and objective piece was 0.986. Conclusion: After different batches of pieces were handled by stepwise blending method,RSD of index components content reduced and fingerprint similarity tended to be consistent,then quality uniformity of Chinese materia medica increased significantly.Stepwise blending method was accurate and simple without complexity mathematical software,which could be a new method for blending of Chinese materia medica pieces. |
| Keywords: | stepwise blending Scutellariae Radix fingerprint HPLC |
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